Manda studied the piano from the age of 5 until she was 18. She began writing music at the age of 18 after teaching herself to play the guitar. She joined several rock groups, and most notably was the singer, songwriter, and bass player for the band Manda & the Marbles.
The group was founded in 1997 and Manda wrote the majority of the material for the groups' 4 albums: Rock's Not Dead, Seduction, More Seduction, and Angels With Dirty Faces.
In 1999, Manda lost all hearing in one ear due to a rare viral illness, but this did not stop her from pursuing her dreams and only made her work harder to reach her goals. 2001 was the band's breakout year; they played at the CMJ Music Marathon and later signed with Go-Kart Records. The band toured the US several times and were well received. During 2003, the band was proclaimed a band on the rise by Rolling Stone Magazine, and Manda Marble was voted as one of the Top 100 Women in Rock by the readers of UK magazine- Miss Minx.
Manda and the Marbles were the first band to release a song using podcasting and were heralded for this achievement on MTV and the BBC.
Manda’s music was featured in several motion pictures, including the low budget thriller Creepies(2003) and the 1980s throwback Nail Polish (2006). Her music also appeared on the MTV show Rich Girls and the band's image and name were shown in the film Come Away Home (2005).
Presently, Manda continues to write and produce music and videos, and plays in a two piece accoustic folk band with her husband, Mark Slak. She has also expanded her creative efforts to include writing poetry, drawing, painting, and photography.